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Within the Prophylaxis with Oral Penicillin in Young children with Sickle Mobile Anemia trial, kids with SCA were randomly assigned to obtain oral prophylactic penicillin or placebo PROPS 1986). The trial finished 8 months early once the prevalence of fifteen cases of pneumococcal sepsis, 13 within the placebo team and two during the penicillin group, showing an eighty four percent reduction in pneumococcal sepsis with penicillin prophylaxis.
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